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Currently doing a Lone Wolf playthrough on Tactician with two Dwarf characters (custom undead and Beast), both with this talent, maxed out Constitution and Warfare with Picture of Health. There are several ways to maximise the potential of this talent:

Obviously max out your vitality, dwarfs with as much Con and Warfare as possible. Prioritise this on your gear.
Death Wish, will give a 100% damage boost when you die with the buff active.
Shackles of Pain, have the other character cast this on an enemy and stand in the explosion radius to get another serve of the damage.
Golden Idols, res you with full health, can be recharged in combat for some reason. Use mercs to kiss the spider so you don't have to give up Con on the dwarfs.
Large Poison potions (Healing for Undead), let you suicide when you need.
Any mobility skills/teleportation to get as many enemies in the explosion as possible.

Other than this gimmick they are just standard strength Warfare/Necro/Poly builds, so you don't need to rely on it to win fights. But it's hilarious and surprisingly effective. Still need to test if this can crit, maybe with savage sortilege?
Tested with Savage Sortilege and Enrage, it can crit.
Why the downvotes? Seem like a cool build. Not gonna check it myself but still.
Love this
The Range of the spell seems to be 3m radius. (Same size as the Enrage skill's range preview)
Same size as Crippling blow skill *-- my bad
Someone already mentioned it but this is used in suicide build, Which is unironically the best damaging build in the game. Max constitution for HP. Max warfare becuz the explosion is physical. Enrage will make it crit. No need to raise wits. Enrage preview is also the same as explosion radius. Talents- Unstable, of course Lone Wolf for double attributes Picture of Health for HP Savage Sortilege to crit Use death wish for +100% damage. Drink Big *** poison potion to kill yourself. And ... BOOM!!! Some one deal 2 MILLION damage with this build
Put this on a character with high CON and 17 Warfare, gave them the shield in Act 4 that sets a permanent Death Wish on yourself and a Glowing Idol of Rebirth, then dropped a deathfog crate on them. One-shot the final boss on Honor Mode :)