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FextraBot

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I have been able to successfully persuade multiple times with characters that have 0 points in persuasion and only 2-3 points stat difference. Maybe you just need at least as much persuasion as the other character or the difficulty of persuasion is not based on teir stats.
Looks like some of the persuasion choices are auto fail or auto succeed, and some are chance based on persuasion skill. Seems like a pretty poorly designed system as it currently stands
In the very first room I have stolen a book next to Magister Siwan. When she accused me of thievery, I vehemently denied that. Persuasion failed and a combat was initiated. Upon reload, I got a persuasion success. That means that persuasion is a chance check.
It would be very nice to have more testing. If you still have the save, could you reload it a few more times and see if it changes again?
Maybe because you had some encourage buff or some other buffs to your attributes ?
I just whip out the D-Piece and I persuade 100% of the time.
Persuasion definitely is attribute based, In drift wood at 1 persuasion and 21 strength I consistently failed the persuasion check for the executioner but after eating a mushroom and a strength pot to get to 24 strength I passed the check. Similarly on the boat to fort joy I would consistently failed the speech check to convince the magisters hiding in the room up stairs to let me go, but after buffing my intelligence by 1 i succeeded.
It seems to me like Persuasion acts as a multiplier, perhaps x1.5 or x2 at 1 point. This would mean that it hugely influences Persuasion checks, but also that increasing your Strength by 3 points would add even more than that to the check.
I kept maxing persuasion on red prince as fast as I could ,never failed with str and con attributes ,the only time I had to reload was in that djien quest that even with passing on str check ,djien tricks you ,overall this system worked fine for me ,my only minor problem is I always have to use red prince to talk to someone first instead of my main charactor Ifan
thw djin will give you a bad reward when you persuade him with strenght or Wits and a good reward when you persuade him with Finesse or Intelligence (atleast I remember it that way)
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Futeko

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A few notable facts about persuasion:
- In order to succeed at a Persuasion check, you need to beat the Persuasion Threshold of the dialogue option with your Persuasion ability score.
- The Threshold depends on (1) the level of the NPC, and on (2) the option itself (some give bonuses, some penalties, some are just impossible to win).
- The related attribute (e.g. Wits, Strength, Intelligence ...) only matters if you meet the Threshold but do not exceed it (e.g. Persuasion 2 vs a Threshold of 2). It is then compared with the NPC's own attribute as a tie-breaker (you win if your attribute is at least 2 points higher than the NPC's).
- Otherwise, if you exceed the Threshold (e.g. Persuasion 3 vs a Threshold of 2), you will succeed regardless of your attribute. If you are below the Threshold (e.g. Persuasion 1 vs a Threshold of 2), you will fail regardless of your attribute.
- There is thus no randomness involved in Persuasion checks (as opposed to D:OS 1).

For a full breakdown of the mechanics of Persuasion and a list of Persuasion checks & Thresholds per area, see https://steamcommunity.com/sharedfiles/filedetails/?id=1166202484
Even though the information linked in the steamcommunity page from Futeko's post below is very thorough, unfortunately I don't believe it is still relevant in the current version of the game.The devs appears to have made some significant changes.
Since the "threshold" level of a persuasion check is now displayed, it's much easier to figure out. Based on some quick tests and conjecture, I believe the general rules of persuasion in the current version of the game works like this:

1. Different options of a persuasion choice have different preset thresholds. This applies even for different options in the same choice of the same NPC. Sometimes, certain options will always succeed, certain options always fail, and not all will lead to the same succeed or fail result. (i.e. Succeeding by threatening someone versus reasoning with them will yield different results, sometimes with very different outcomes). The game now tells you when a certain option is impossible to succeed.

2. In order to succeed at a persuasion check, you need to reach the required threshold.

3. Each point in the Persuasion skill counts as 1 point towards the threshold. Each two points of the relevant attribute ABOVE the NPC's same attribute counts as 1 point towards LOWERING the threshold. Temporary buffs and equipment bonuses count towards the total point checks, so stack up if you're trying to pass a particularly difficult one.

Example:
In order to get past Grog the troll, you chose the Intelligence persuasion option. It requires a threshold of 6.
Grog's Intelligence attribute is 24. A character with a total of 26 Intelligence will lower the threshold by 1, making it 5.
So in order to succeed at this option, that character with 26 Intelligence will also need a total of 5 Persuasion skill in order to succeed at this choice.

All of this is based on some quick testing. There may be mistakes or the game may change in future patches again. This is why I didn't add this directly to the official wiki page. Feel free to add your own correction.
Well i doubt it ... with lone wolf my rouge has over 70 finesse and for example to pass check on elf guarding last rites I still need 4 persuation. While i have 9 (-2 from kiss +1 from blood rose) costitution and 1 persuation (from amulet :D) and I passed costitution check on that elf ;v.
This is simply not true. The most important persuasion I have encountered in the game so far is in Act III after doing all the plot points necessary to enter the Academy. Well, one needs to persuade each of the three followers to keep going so the main character can attempt the next step with them along (sorry for the vague but avoiding spoilers here). Even though my main character has 1 persuasion point, and his intelligence is vastly above the other characters (being an Enchanter), he is only getting 1 persuasion toward the goal with each follower on an intelligence-persuasion check, and I'm just so stuck I'm about to delete the game from my ps4. Note to the game designers: if your game requires google searches to figure out, and it is a one-player game, you have FAILED at game design!
Quicksave before the dialogue, go to the respec mirror, max out your persuasion, go back, convince them, go respec again back to how you were. Problem solved.
Yeah, I'm sure some anon who can't commit to his choices in game knows more about game design. Commit to the build choices you make or respec like a scrub every time you encounter a chokepoint.
Sure.. and if you're unable to swimm, blame the water ;)
No, the commenter is quite right actually. For instance, my main character is a Tank with lots of strength. I need to convince Ifan who is an archer with Finesse maxed out. The persuasion dialog opts to [Finesse] and [Intelligence] persuasions. So it's I cannot win this game, do you get it? Then, if I go to the mirror and maximize my persuasion attrs I'll get just 4. While it's clearly needs to be 6 (SIX). So how are you smart heads going to win this bloody dialog? Come one, tell us!