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that kinda detailed
Spider can be found in the attics, you have to climb the stairs with a force char. Didn't find any quest related to it tho
She give you a quest, requeriments.
Spider kiss from the quest : A Web of Desire
Pet pal.
Limbs from different enemies or bodies (rykers dungeon plenty of them)
She smell the Spider Kiss from you and is friendly to you, then she ask for limbs (trade) then she ask for 3 more (trade again) and she give you Spider silk glove:
128 MA
26 PA
+30% poison resistance
Inflick poison on contact
Unique
This quest is called "The Weaver" - there is another walkthrough page on this very site