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unless you have a specific need for a rune, luck runes are the best for most situations
weapons: scaling if you have played any dark souls you know how important this is and with how low base scaling is in this game they help greatly
armor: adds more weight capacity which lets you move faster in heavy armor, but with light armor it starts to be silly
shield: less stamina loss on block, makes blocking less risky, but is not as good as its other two uses
follow up, because you can replace runes at will, there is no penalty for trying different things to find your favorite setup.
hi, can you tell me how to drop items from my inventory because im carrying too much crap.
aaand i just realised i put this in the item page instead of the rune page, *****
is it possible to keep adyr's rune after defeating the last boss?