Perhaps it's better to be a blue alien than lunch for a giant pig.

Ok so hear me out. Is it possible to initiate dialouge w her to send her to Iosefkas clinic after gaining acces to the forbidden woods? If so, what would happen if you send her to the clinic, then go all the way to the clinic, and kill Iosefka before reloading the game so she doesnt kill her? Has anyone tried this, if it is possible? Please let me know, I already missed the opportunity on my current playthrough, but I will definately try it on my next one if no one has run the experiment.

Her sister's corpse will spawn with a quick reload. You don't have to return to the lantern like some say.

During my first playthrough of the game, I ended her questline early by giving her the red brooch; I felt it wouldn't be any kinder to the little girl to let her keep believing her parents were alive, when they very much were not. She deserved the truth, though it would hurt terribly. As a result, I never even realized I could try sending her to the chapel until I looked at the wiki. I'm rather glad I didn't, in hindsight. Instead of putting herself in danger, she could hole up at home, hide herself away until morning came.

Gods, I even went as far as to clear EVERY. SINGLE. ENEMY. in Yharnam just hoping she could somehow survive and nobody found it yet. Sadly not.

Bruh, she ALWAYS DIES!? This is BS!

Bloodborne is the most messed up of all the fromsoft stories.
Nobody has a happy ending in it. Literally nobody, even your own player character has endings where he satisfies the great ones desires or dies.
Damn.

I forgot to talk to the Little Girl & didn’t direct her to safety. I had defeated Rom, returned to Yharnam before the Blood Moon cutscene, reloaded the game after hearing her talk (she said “Mother, please come home. I’m all alone, I’m scared. It’s not fair…”), and found that the Little Girl wasn’t home; I checked the sewers hoping that she was eaten by the boar in the sewers, yet she wasn’t there. Is there something I’m missing? Did she commit suicide in her own home?