Devil May Cry 5 All Enemies Guide

Devil May Cry 5 All Enemies Guide

All Enemies Guide for Devil May Cry 5, featuring the in-game model images and descriptions by Nico, as well as where to find the enemies and some tips on how to take them on. If you want to learn more about DMC5, see our Bosses and Weapons guides as well!

All Enemies in DMC 5

There are a total of 19 unique enemy types in the Devil May Cry 5, and each enemy has its own moveset, strengths, and weaknesses. Some enemies can block and deflect attacks, some enemies have special rage modes, and others can only attack on melee or range. Learning their attack types and weaknesses is key to success, so read on for a full list of all creatures found in game and the best way to deal with them.


  • Found in all non-boss missions.
  • They aren’t a real threat my any means, and are grappable at all times.
  • Melee Attacks Only

“Seems you’ll be running into a lot of these ugly suckers— and I mean “suckers” literally!

The good folks of Red Grave have had their blood sucked dry by these lil’ worker ants. Once the creatures have a butt full of the red stuff, they carry it off to the Qliphoth.

Well, on the plus side, they are pretty dumb—they might even ignore you and keep working until you turn on the heat. Be careful, though. Worker ants don’t seem so weak when you’re being swarmed by ’em.”

Green Empusa

  • Found in the Prologue and subsequent missions (frequent in harder difficulties)
  • Does not attack the player
  • Should be a priority for defeat, can be grappled at all times.

“If you thought those other bugs were bad, you’re really gonna hate these guys.

The green stuff in their butt ain’t any kind of blood—it’s a healing nectar that’ll fix up other demons’ wounds in no time at all.

My recommendation: Kill these first, before they make themselves a nuisance.

Oh, and it looks like they spit some kinda poison juice too. So, uh, maybe bring an umbrella.”

Red Empusa

  • Drops large amounts of orbs
  • Found in most missions, special Red Empusa groups reward players with blue / purple / gold orbs. See Walkthrough for details.
  • Higher difficulty Red Empusa attack the player
  • Interrupt their escape with a high-impact combo
  • Grappable at all times

“Ooh mama, this is a rare ‘un.

Just goes to show the power o’ blood—this one’s sucked up so much of the red vino that it’s crystallized its body. You could probably knock some of the crystals off with a few hits, or take this guy down and get the whole lot.

Trouble is, from what I’ve seen, these shy lil’ monsters are mighty skittish. First sign o’ danger and they’re outta there. Better work quickly if you want the big payoff.”

Empusa Queen

  • First found in Mission 05 (V). Appears from Prologue in harder difficulties
  • Can enrage (become red), dealing more damage and doing chained combos
  • Cannot be grappled
  • Can summon Red Empusa
  • Attack from the back to minimize the chances you take damage, if it grabs you use Devil Trigger or Arms to break free

“I knew it! Where there’s worker ants, there’s gotta be a queen too.

This big gal’s got the armor to take a beating and the tools to dish one out. And when she’s angry, she ain’t picky about her targets—she’ll scythe through her own demon buddies to get to you.

If that ain’t enough, she’ll get fired up if she sucks enough blood. Watch out if her body turns red—that’s your sign that it’s go time.”

Hell Caina

  • Melee Attacks with Scythe only
  • Easily Grappable
  • Their “charge” attack makes them immune to staggers
  • Easy to dispatch

“These shambling meatsticks are residents o’ the underworld, foot soldiers straight from the legions of Hell.

Time was, these things only appeared on the mortal plane by possessing a wooden doll, lump of clay, or something similar.

Now? Those creeps walkin’ around Red Grave are the genuine article. It’s a sign that the barriers between the demon world and the human world are breaking down.”

Hell Antenora

  • Appears first on Mission 02, consistently shows up afterwards
  • These guys can be grappled once, but after any combo they will enrage (glow purple) and charge at you. Their charge is ungrappable and prevents them from staggering from your damage.
  • They only have melee attacks, so charged ranged attacks can work well. Easy to separate them from others
  • Their charge will hit you from off-screen if it started on-screen

“Take a Hell Caina, torture it till it goes mad, throw weapons in its hands, and this is what you get.

Their hatchets are real nasty, and they’re nimbler than they look. Expect quick attacks when they go into a frenzy.

Judging by the samples we got, these things are extremely susceptible to pain—so you better believe they won’t take any punishment lying down.

Knock ’em down, but keep your guard up. Next thing you know it’ll be back swinging like a madman on fire.”

Hell Judecca

  • Appears first on Dante’s mission
  • Annoying escape-prone enemy, use trickster / stinger / grapple to get to it.
  • It can inflict ranged and melee damage, but its attacks are slow.
  • It is best to lure other enemies away from this one to thing out crowds on higher difficulties.
  • Using your devil trigger to deal with them is advised only in close quarters as they will otherwise teleport away.
  • Does not attack from off-screen, but be mindful of getting caught up in an “almost” off-screen attack

“A high priest in the choirs o’ Hell. Ain’t that somethin’?

These fellas tend to leave close-quarters fighting to the grunts, which they can summon in to take the heat off themselves. Meanwhile, they attack from long range by extending those snakey tentacle arms.

They’ll try to keep their distance and dodge gunfire when they can. You’ll just have to show these slitherin’ scumbags you got the smarts to get past their defenses and send ’em screaming back to the pit.”


  • Staple enemy, ranged attacks only
  • Can be grappled at any time
  • Can be knocked off the air with Griffon’s dive ability
  • Best to deal with them first in a fight, or use them to trickster / grapple away from battle
  • If let unattended, they will eventually break your combo with one attack or other

“Ever heard the phrase “like a bat outta Hell”? Well, this is it.

These leathery lir pests have got some kinda combustion chamber built into their biology. Meaning? Well, they breathe fire.

On their own, these critters ain’t gonna burn your ass up too bad. Just watch your back when a whole swarm tries to crash the party.”


  • Regular on several missions
  • Incredibly annoying ranged attacks
  • Deal with this enemies as soon as possible by knocking them off the air and unleashing.
  • Trickster or Jump away when they die, as they trigger a large explosion on defeat
  • Can be grappled at any time

“Y’know, we see a lotta weird things coming up out of the hot place, but this one’s really somethin’ special.

See how the combustion chamber is mounted on its spine, so when it spits flame it sets itself on fire? That’s the kinda design I can get behind.

Not that I’ll object if you smash these little assholes to kingdom come. Try aiming for the combustion chamber on its back—should take the fire out the critter and make for easy pickings.”

Death Scissors

  • First seen in Mission 4, regular in several missions and common in high difficulties
  • The scissors provide blocking for this enemy, making it difficult to deal with
  • You can break their block with the right combo or powerful charged blasts, but it is risky to wait out the charge time
  • Pro Tip: Wait for it to attack then attack at the same time, this will “parry” the attack – now shoot them in the face for a 1HKO (the one you need for Secret Mission 7)
  • You should practice breaking their defense in The Void to learn what combo works best for you
  • Cannot be grappled
  • Attacks from off-screen as it teleports to you and attacks from underneath or a side

“Now a master engineer like me’s gotta have a profound respect for the laws o’ physics. So when these creepy specters come drifting through walls with their shears a-choppin’, it kinda gets on my nerves.

But they’ve gotta be solid sometime—otherwise they couldn’t block your attacks with them shears.

Near as I can tell, that noggin controls the whole shebang. Look for some cue from the head, and aim your attacks there. Might go down easier’n you think.”


  • Common Enemy
  • Its attacks can be stopped by heavy blows, particularly susceptible to Dante’s motorcycle attacks
  • Can be grappled
  • Melee attacks only
  • Easily separated from groups
  • Has a long downtime when knocked which can be used to deal further damage

“The pits of Hell spew up all kinds o’ reptilian nasties, and this is one of them.

I studied their cell samples and let me tell ya, their muscle tissue is something else. Each limb has power like a hydraulic cylinder. That’s how they jump so dang far.

And I ain’t exaggeratin’ when I say their retractable claws are razor sharp. I tried one on some sheet metal—zzzzip! cut right through. Weak to impacts though. Think you can break ’em off?”


  • Appears in later missions
  • Very annoying spin attacks can come at you from off-camera
  • Can be stunned with heavy artillery, but the charge time has to be properly planned for
  • Can be grappled when not spinning
  • Best to launch them into the air to toy with them without the danger of being on the ground

“Another big lizard that’s crawled outta some deep dark hole in the underworld.

Each one of those spikes on its back is like a giant saw tooth, and it’s not afraid to get ’em spinning!

They’re sharp but brittle, so try snapping ’em off in between dodging its attack runs.

Oh, and it’s got these nasty little neurotoxin sacs inside its chest. Step aside when it starts hackin’ something up —that stuff is lethal!”


  • Extremely fast and deadly enemy
  • First appears in late missions, but is recurrent on higher difficulties
  • It teleports a lot, so using trickster is a must to stay ahead of it
  • It is very difficult to grapple it or land consistant combos
  • Stinger and such are good moves to get some damage in fast

“I got this theory that demons mutate based on their deepest, darkest desires.

So take this big lizard. It wants to hunt, right? It wants to go faster. Wants to kill faster. Day in, day out, all it can think of is speed.

A few generations of that twisted killer instinct, and you get a freak so fast it ain’t even moving under its own power no more. This sucker uses raw demonic power to do little space-time jumps. It’ll warp right next to you and bite your face off before you can blink! Hope you got quick reflexes.”

Scudo Angelo

  • Appears first as a mini-boss of a coop mission
  • Only deals melee damage, but can charge at you
  • The shield can be destroyed with sufficient damage
  • Jump behind them to get easy hits
  • Can be grappled if not shielded
  • Can be launched into the air for combos and grab.
  • Deal with them before taking on Proto Angelo

“In his journals, my daddy sometimes mentions the Black Angel—some kind of powerful demon that used to inhabit the underworld.

Daddy had a theory that it was created by transubstantiating an unwilling human victim into demonic flesh.

If that theory was right, then these dead-eyed creeps are like a mass-produced version of the Black Angel.

Their shields? Hella tough. If you wanna get around ’em, you’re gonna have to use your head. Good luck with that.”

Proto Angelo

  • Appears first as a mini boss on a coop mission
  • Deals large AOE attacks and has powerful charges
  • Can poise through combos
  • Cannot be grappled unless staggered
  • It is best to attack from behind

“Check out the armor and weapon on this demon. I’m seein’ clear similarities to the Black Angel.

My guess is these are some kinda prototype, or maybe modified version of the Black Angel.

We’ve seen these weirdos speaking to the mass-produced types, giving them orders like they’re in command. Seems they’re smarter than your average hell-beast.

And hey, I know you think you’re invincible, but that sword’ll give you more than a close shave. But, if you can parry it, I reckon you’ll have a pretty big opening to do your stuff.”


  • Appears in later missions
  • Summons ranged ice daggers that follow you
  • Summons ice spikes under you
  • Best to get up and close via trickster / grapple as soon as possible and knock them to the ground
  • Can be grappled
  • Deal with them first when multiple enemies are there
  • Does not attack from off screen

“Your average demon don’t have the smarts to actually wield their power as magic.

This fella breaks the mold, though—he may only have ice tricks up his sleeve, but that’s still enough to kill you if you don’t watch your ass.

Just look at those freaky, stick-thin limbs. Physically speaking it’s weak, and it knows it, too. It’ll try to keep its distance and throw up a magic shield to block your shots. You’ll have to get in its face, or wait for your chance to shoot past the shield.

Hey, nobody said this business was easy.”


  • Appears in later missions
  • A very powerful ranged mage
  • Puts an aura around you that deals large damage, stay on the move!
  • Trickster or grapple to it and melee it into the ground as soon as possible
  • Deal with them first in a multiple enemy scenario

“Sure was interesting dissectin’ this demon.

This thing bears out my theory on demon evolution. Can’t do magic incantations without a

mouth, right? So after a few generations of demons obsessed with arcane chants, you get something that’s all mouths, with its muscles so atrophied it can hardly move its limbs.

And more mouths means more power. My guess is this thing could kill you dead with a single spell if you let it get the chant out. If you see it startin’ something real ominous-looking, you better shot it down real quick.”


  • The enemy has a caged state where it does little damage, you can ignore it while in this form
  • When you break its bonds, it will hit for a lot of HP if it connects, so stay on the move
  • Can be grappled in devil trigger
  • Moves very fast, dodge its charges and avoid being near its head

“Every now and again you get a demon so absorbed with gluttony and power that it starts cannibalizin’ its own demon kin.

See how other demons have chained up this thing’s mouth? It’s good to know that even the demons are afraid of becoming chow.

With the restraints in place, this big boy’ll just stumble around lookin’ sorry for hisself. Not too dangerous.

Bust the chains off, though, and it’ll go hog wild, eatin’ everything in sight. If it chomps a few bad guys, all the better. Just don’t come cryin’ to me when it nips your buns.”


  • Appears in later missions
  • Damage sponges, separate them and isolate them to focus fire
  • Deals melee damage but can fire eye balls at you that explode for AOE damage
  • They can be grappled if stunned
  • It is best to leave them for last in a group as they have high HP

“At first glance, these uglies seem half-formed, like they broke outta the egg too early. I gotta admit, there’s still a lot I can’t figure out about lem.

Half-baked or not, theylll tear you a new one if you don’t watch out. They got more strength in those spindly arms than your three average demons combined.

And what else is on the menu? Magic powers. When you see ’em kinda dancing around, they’re absorbing demonic power right outta the atmosphere.

What really bugs me is those masks they wear. The masks are important to ‘em somehow…Just wish I could figure out how.”


If you’re enjoying DMC5, make sure to check out our Devil May Cry 5 Review, the DMC5 Walkthrough, and our other DMC5 Guides: 10 Things you Should knowSkills List, All DMC5 Weapons Guide, All Secret Mission Guide, All Blue Orb Locations, All Gold Orb Locations, All Purple Orb Locations and All DMC5 Enemies, All DMC5 Bosses.

MMO raider by day and guide writer by night, Fex enjoys multiplatform gaming, good books and animes, and streaming with a cold beer.

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